Reply: Escaping a Low-Security Prison

Reply: Escaping a Low-Security Prison.

First, he states that a given protein will be predisposed to escape and move long distances when it is overexpressed on free ribosomes in the companion-cell (CC) cytosol. He suggests that retention rather than movement would be the default. This begs the question as to how the CC could retain all of its translated proteins when it is connected to the fast-flowing sieve element (SE) by numerous,...

Retirement Security and Tax Policies: A Reply

Escaping a checkpoint

O n page 999, Holway et al. reveal that worm embryos would rather risk genomic mutation than disturb the timing of cell division. DNA damage–induced checkpoints, the group fi nds, are silenced during early embryogenesis. The need for the silencing arises because of the importance of timing in embryogenesis. At the worm’s two-cell stage, for instance, a two-min...

The Authors’ Reply

Escaping inefficiency.

Two very different articles in this issue deal with the same important subject: workflow redesign. It’s a topic that is at the same time important and often slighted, largely because workflow – the way we do what we do day after day – tends to become such a well-traveled route that we may forget that other ways may lead us to the same end more quickly and efficiently. When workflow issues do ...